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Kelvin Yoon Chiang Lee, Atsuo Tomidokoro, Rei Sakata, Shinsuke Konno, Chihiro Mayama, Hitomi Saito, Keiko Hayashi, Aiko Iwase, Makoto Araie; Cross-sectional Anatomic Configurations of Peripapillary Atrophy Evaluated with Spectral Domain-Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(2):666-671. doi: 10.1167/iovs.09-3663.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the cross-sectional configurations of peripapillary atrophy (PPA)-α and -β in ophthalmologically normal subjects using spectral domain-optical coherence tomography (SD-OCT).
One hundred twenty normal subjects had a complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography, and SD-OCT (3D OCT-1000; Topcon Inc., Tokyo, Japan). PPA-α and -β were identified in color photographs of the optic disc. Cross-sectional B-mode images of the peripapillary retina and sclera, including PPA-α and -β obtained with SD-OCT, were analyzed.
Of 120 normal eyes, 120 (100%) had PPA-α and 90 (75%) had PPA-β. In OCT images of the peripapillary retina, the ganglion cell layer and the inner and outer plexiform layers were observed to end in a tapering fashion at the edge of the optic disc, whereas the retinal nerve fiber layer continued into the optic cup. The external limiting membrane (ELM), inner–outer segments (IS-OS), and retinal pigment epithelium(RPE)/Bruch's membrane complex were significantly more commonly absent before the optic disc edge within the PPA-β compared with areas outside the PPA-β (P < 0.0001). Specific findings in the peripapillary area including slope and step configurations of the scleral bed and hump- and wedge-shaped appearances of the RPE–Bruch's membrane complex were identified in 63 (52.5%), 6 (5.0%), 19 (15.8%), and 6 (5.0%) of 120 eyes, respectively. The presence of the step configuration was associated with myopia and longer axial length (P = 0.0014 and 0.0105, respectively).
The cross-sectional anatomic configurations of the peripapillary atrophy were evaluated by using SD-OCT. The termination of the retinal layers and configurations of the scleral bed in the peripapillary area varied among normal subjects.
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