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Yuzuru Sasamoto, Fumi Gomi, Miki Sawa, Motokazu Tsujikawa, Toshimitsu Hamasaki; Macular Pigment Optical Density in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(10):5219-5225. doi: 10.1167/iovs.09-4881.
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To evaluate macular pigment optical density (MPOD) in patients with central serous chorioretinopathy (CSC) and in normal subjects.
MPOD was measured by autofluorescence spectrometry by using a two-wavelength method. Central retinal thickness (CRT) was measured with optical coherence tomography. Statistical analyses were performed to determine factors associated with MPOD.
Ninety-four eyes of 94 normal control subjects, 123 eyes of 70 patients with chronic CSC, and 74 eyes of 41 patients with acute CSC were included. The mean MPOD was 0.548 density unit (DU; 95% confidence interval [CI]; 0.516–0.580) in the control group. Stepwise regression analysis of the control group showed that CRT was associated positively with MPOD (P = 0.0079). The mean MPOD was 0.386 DU (95% CI, 0.352–0.420) in the eyes with chronic CSC, 0.443 DU (95% CI, 0.401–0.484) in fellow eyes with chronic CSC, 0.542 DU (95% CI, 0.493–0.590) in affected eyes with acute CSC, and 0.528 DU (95% CI, 0.475–0.582) in fellow eyes with acute CSC. Stepwise regression analysis showed a significant association between eyes with a lower MPOD and affected eyes with chronic CSC (P = 0.0126) and fellow eyes with chronic CSC (P = 0.0023) and a thinner central retina (P = 0.0016).
MPOD may decrease in eyes with chronic CSC and in the fellow eyes. Low MPOD may indicate a risk of chronic CSC, and a decrease in MPOD may be accelerated by thinning of the central retina.
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