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Victor Koh, Carol Yim-lui Cheung, Yingfeng Zheng, Tien Yin Wong, Wanling Wong, Tin Aung; Relationship of Retinal Vascular Tortuosity with the Neuroretinal Rim: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2010;51(7):3736-3741. doi: 10.1167/iovs.09-5008.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the association of retinal vascular tortuosity, measured quantitatively, with the neuroretinal rim.
A population-based, cross-sectional study was conducted in Malay persons aged 40 to 80 years residing in Singapore. Retinal vascular tortuosity was quantified by using a semiautomated, computer-assisted program assessing retinal fundus photographs, according to a standardized protocol. Optic disc measurements including disc area, rim area, and rim-to-disc area (RDA) ratio were obtained with a confocal scanning laser ophthalmoscope.
In analyses adjusting for age, sex, spherical equivalent, and retinal vascular caliber, reduced arteriolar and venular tortuosity were associated with a decrease in global RDA ratio (P = 0.006 and P = 0.001, respectively). When compared with the arterioles, retinal venular tortuosity demonstrated a stronger association with RDA ratio. The temporal-inferior region of the neuroretinal rim was most strongly associated with retinal vascular tortuosity.
Straighter retinal vessels were significantly associated with a thinning neuroretinal rim. These findings may provide additional insights into the geometric retinal vascular changes seen in early glaucomatous optic neuropathy.
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