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Eun Ji Lee, Tae-Woo Kim, Robert N. Weinreb; Improved Reproducibility in Measuring the Laminar Thickness on Enhanced Depth Imaging SD-OCT Images Using Maximum Intensity Projection. Invest. Ophthalmol. Vis. Sci. 2012;53(12):7576-7582. doi: 10.1167/iovs.12-10305.
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To investigate whether the thin-slab maximum intensity projection (MIP) image improves the reproducibility of the measurement of spectral domain optical coherence tomography (SD-OCT) based lamina cribrosa thickness (LCT).
Optic discs of 63 open angle glaucoma patients or glaucoma suspects were scanned with enhanced depth imaging spectral domain optical coherence tomography (SD-OCT). The B-scan images were constructed three-dimensionally using maximum intensity projection (MIP). The whole MIP volume was then cut into thin slabs of two scan-line distance width (approximately 64 μm) at three 3 locations: mid-horizontal, and superior and inferior mid-peripheral regions of the optic nerve head. The LCT was measured in the thin-slab MIP images (LCT-MIP) and the three B-scans corresponding to each thin-slab MIP image (LCT-Bscan) at the three regions in each eye. The interobserver and intraobserver reproducibility of measuring the LCT-MIP and LCT-Bscan were evaluated by calculating the intraclass correlation coefficient (ICC), coefficient of variation (CV), and coefficient of repeatability (CR). The agreement between the LCT-MIP and the LCT-Bscan was assessed by Bland-Altman analysis.
The thin-slab MIP images provided better image contrast with more distinct borders of the lamina cribrosa compared to the B-scan images. Both intraobserver and interobserver ICCs were higher for LCT-MIP than for LCT-Bscan in all areas. The 95% limit of agreement of measurement differences between LCT-Bscan and LCT-MIP ranged from −29.43 to 32.55 μm.
The thin-slab MIP images provided a higher reproducibility in measuring the LCT using SD-OCT than the B-scan images. With thin-slab MIP images, the detection of the laminar borders was more straightforward. This technique should facilitate the evaluation of the lamina cribrosa.
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