December 2010
Volume 51, Issue 12
Free
Letters to the Editor  |   December 2010
Author Response: Linear Relation between Structure and Function
Author Affiliations & Notes
  • Helen V. Danesh-Mayer
    New Zealand Eye Center, University of Auckland, Auckland, New Zealand;
  • Michael V. Boland
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland;
  • Peter J. Savino
    Wills Eye Institute, Thomas Jefferson Medical School, Philadelphia, Pennsylvania; and
  • Neil R. Miller
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland;
  • Prem S. Subramanian
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland;
  • Christopher A. Girkin
    the Department of Ophthalmology, University of Alabama, Birmingham, Alabama.
  • Harry A. Quigley
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland;
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6891-6892. doi:10.1167/iovs.10-5148
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      Helen V. Danesh-Mayer, Michael V. Boland, Peter J. Savino, Neil R. Miller, Prem S. Subramanian, Christopher A. Girkin, Harry A. Quigley; Author Response: Linear Relation between Structure and Function. Invest. Ophthalmol. Vis. Sci. 2010;51(12):6891-6892. doi: 10.1167/iovs.10-5148.

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      © ARVO (1962-2015); The Authors (2016-present)

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We thank Wegner and Erben for their comments and draw their attention to the Discussion in our article. 1 In that section, we addressed their concern by stating that “most of our imaging studies were performed longer than 6 weeks after presentation, with 52 (91%) of 57 NAION and 16 (80%) of 20 AAION eyes imaged with HRT and/or OCT 3 months or more after the event.” We further discussed that there may have been some additional thinning of the RNFL, which continues subsequent to this time point. However, when we limited the patients included to those with data recorded greater than 3 months after the acute AION event, there were no significant changes in the results. 
We also disagree that the data of Hood et al. 2 are similar to ours. They did not evaluate optic disc topography, but rather modeled the relationship of peripapillary retinal nerve fiber layer thickness to visual field mean deviation. The conclusion we drew from our work was that there was a difference in the topography of the optic disc between open angle glaucoma and the anterior ischemic optic neuropathies, not that there were differences in nerve fiber layer thickness. We believe our conclusion about differences in disc topography is strengthened by the fact that we explicitly controlled for the total amount of damage in each condition, using either visual field mean defect or average nerve fiber layer thickness. Furthermore, Hood et al. did not differentiate between AAION and NAION in their study. 
References
Danesh-Meyer HV Boland MV Savino PJ . Optic disc morphology in open angle glaucoma compared with anterior ischemic optic neuropathies. Invest Ophthalmol Vis Sci. 2010;51:2003–2010. [CrossRef] [PubMed]
Hood DC Anderson S Rouleau J . Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy: a test of a linear model. Ophthalmology. 2008;115:904–910. [CrossRef] [PubMed]
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