As described, numerous artifacts can be observed in fetal eyes, and most of them are the result of autolysis, either intrauterine or predominantly postpartum. Artifacts in tissues of the cornea, conjunctiva, sclera, choroid, or RPE do not have a huge impact on evaluation quality. In contrast, other ocular structures such as the retina and the lens are more severely affected by artifacts and thus are more difficult to evaluate histopathologically. In particular, the evaluation of the fetal lens is challenging because of autolytic changes (such as globules, clefts, and subcapsular exudates) that mimic cataractous changes in adult eyes. These variations of the lens structure should not be used for the diagnosis of a fetal cataract. This diagnosis should only be established in the presence of a pattern of definitive cellular variations. The anterior chamber and the ciliary body can also be affected by autolysis, making an evaluation of these delicate structures with respect to developmental aspects extremely difficult.