Purchase this article with an account.
Jaewan Choi, Jong Rak Lee, Youngrok Lee, Kyoung Sub Lee, Jung Hwa Na, Seungbong Han, Michael Scott Kook; Relationship Between 24-Hour Mean Ocular Perfusion Pressure Fluctuation and Rate of Paracentral Visual Field Progression in Normal-Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(9):6150-6157. doi: 10.1167/iovs.13-12093.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between unstable mean ocular perfusion pressure (MOPP) and the rate of paracentral visual field (PVF) progression in patients with medically treated normal-tension glaucoma (NTG).
The data of 157 eyes of 122 patients with NTG who were followed for more than 6 years (mean follow-up, 8.7 years ± 12.6 months) and had more than 5 reliable standard visual field (VF) tests were analyzed retrospectively. Groups in the highest, middle, and lowest tertiles of 24-hour MOPP fluctuation (HMF, MMF, and LMF, respectively) were compared in terms of rates of change of mean thresholds in the central 10° (PVF), 10° to 24°, and global areas by using a linear mixed model. Clinical factors associated with rapid PVF progression were also investigated.
The LMF and HMF groups did not differ significantly in the mean global rate of VF changes (−0.52 vs. −0.71 dB/y; P = 0.07). The HMF group had a significantly faster progression of VF defects in the central 10° area than the LMF group (−1.02 vs. −0.54 dB/y; P < 0.001) but did not differ in terms of progression of VF defects in the peripheral 10° to 24° area (−0.39 vs. −0.495 dB/y; P = 0.425). PVF progression was significantly associated with 24-hour MOPP fluctuation (β = −0.31, P < 0.001) and VF damage severity at initial presentation (β = 0.134, P = 0.011).
Medically treated NTG eyes with greater 24-hour MOPP fluctuations (HMF) had faster PVF defect progression than eyes with stable 24-hour MOPP (LMF). Twenty-four hour MOPP fluctuation associated significantly with PVF progression velocity.
This PDF is available to Subscribers Only