August 1966
Volume 5, Issue 4
Articles  |   August 1966
Endothelial cell lined lymphatics in the vascularized rabbit cornea
Author Affiliations
  • H. Barry Collin
    Victorian College of Optometry, University of Melbourne Melbourne, Australia
Investigative Ophthalmology & Visual Science August 1966, Vol.5, 337-354. doi:
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      H. Barry Collin; Endothelial cell lined lymphatics in the vascularized rabbit cornea. Invest. Ophthalmol. Vis. Sci. 1966;5(4):337-354.

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      © ARVO (1962-2015); The Authors (2016-present)

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The possibility that the lymph vessels may proliferate and invade corneal tissue in association with a similar invasion of the blood vessels following the intraocular injection of alloxan monohydrate has already been presented1. On that occasion the response of both the lymph and blood vessels to external corneal damage was ignored. Moreover, no definitive proof was presented to show that the observed corneal canals were lined by endothelium. In this paper it is shown that canal formations other than corneal blood vessels occur as part of the reaction to external corneal tissue destruction caused by cauterization and silver nitrate application. The irregular caliber and frequent anastomoses of these canals show a similarity to the capillaries of the lymphatic system. Injection of a dilute solution of silver nitrate into the corneal canal system shows that a wall consisting of a single layer of endothelial cells is present. This cellular lining is continuous with that of the confunctival lymphatic vessels, the cell borders of which show the sinuous and irregularly dentate pattern which is characteristic of the cells of lymphatic endothelium. Many of the cells lining the corneal lymphatic vessels show the same irregular shape and tortuous cell margins


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