The overall analysis investigating the recessive model for the C allele (CC versus CG+GG) showed significant association between TP53 codon 72 polymorphism and increased open-angle glaucoma risk (OR = 1.31, 95% CI 1.05−1.64,
P = 0.017;
Fig. 2), although no evidence of associations was detected in the allelic, additive, and dominant models (allelic model: OR = 1.10, 95% CI 0.99–1.22,
P = 0.054; additive model: OR = 1.23, 95% CI 0.97–1.56,
P = 0.079; dominant model: OR = 1.06, 95% CI 0.94–1.19,
P = 0.317) On the other hand, the association between the 16-bp insertion and decreased risk for POAG relative to the 16-bp deletion (Ins versus Del) revealed a significant association (OR 0.75, 95% CI = 0.57–0.97,
P = 0.031;
Fig. 3). No significant associations were observed between TP53 intron 3 16-bp insertion genotype and risk for POAG in the additive (OR = 0.49, 95% CI 0.18−1.32,
P = 0.16), recessive (OR = 0.51, 95% CI 0.19−1.37,
P = 0.18), and dominant models (OR = 1.01, 95% CI 0.87−1.17,
P = 0.91). Because the Q-test of heterogeneity among studies was nonsignificant in all genetic models, a fixed-effects model was used (
Table 2).