December 1967
Volume 6, Issue 6
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Articles  |   December 1967
The Effects of Ionizing Irradiation on Lens Cation Permeability, Transport, and Hydration
Author Affiliations
  • BRENT W. LAMBERT
    Howe Laboratory of Ophthalmology, Harvard Medical School, and the Massachusetts Eye & Ear Infirmary Boston, Mass.
  • JIN H. KINOSHITA
    Howe Laboratory of Ophthalmology, Harvard Medical School, and the Massachusetts Eye & Ear Infirmary Boston, Mass.
Investigative Ophthalmology & Visual Science December 1967, Vol.6, 624-634. doi:
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      BRENT W. LAMBERT, JIN H. KINOSHITA; The Effects of Ionizing Irradiation on Lens Cation Permeability, Transport, and Hydration. Invest. Ophthalmol. Vis. Sci. 1967;6(6):624-634.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of in vivo x-irradiation on rabbit lens permeability was studied by the 86Rb runout method. At 24 hours following x-irradiation of the lens the rate of 86Rb runout was found to be increased and reached a maximum at one week. Over the subsequent 2 weeks the rate of 86Rb runout decreased, although still remaining above normal. The increase in lens permeability preceded the appearance of lens opacities and was found to be dose dependent. The active transport of cations as measured by 86Rb uptake was unaffected. Alteration in lens permeability was accompanied by an increase in lens water. The effect of in vitro B irradiation on the permeability of the anterior or posterior lens surface was investigated and found to parallel in vivo x-irradiation to the entire lens

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