December 1967
Volume 6, Issue 6
Articles  |   December 1967
Drug effects on retinol oxidation: Retinal alcohol:NAD+ oxidoreductase
Author Affiliations
    Department of Ophthalmology, University of California School of Medicine San Francisco, Calif.
Investigative Ophthalmology & Visual Science December 1967, Vol.6, 635-641. doi:
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      J. FRASER MUIRHEAD; Drug effects on retinol oxidation: Retinal alcohol:NAD+ oxidoreductase. Invest. Ophthalmol. Vis. Sci. 1967;6(6):635-641.

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      © ARVO (1962-2015); The Authors (2016-present)

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A spectrophotometric method was used to follow the oxidation of retinol by preparations of cattle retinas. Two-tenths millimole chlorpromazine (CPZ) and thioridazine (TRDZ) activated the initial rate. This was followed by inhibition. These effects are reversible. The ring sulfoxide of chlorpromazine and thioridazine thiomethyl sulfoxide (TPS-23) had no apparent effect. Lower concentrations (0.01 and 0.1 mM.) of CPZ and TRDZ have no demonstrable effect on the standard reaction, and no differences between CPZ and TRDZ could be shown. Chloroquine (0.2 mM.) and sodium lauryl sidfate (1.0 mM.) toere shown to activate the reaction ivithout changing the pseudomonomolecular characteristic of the standard reactions. These data were discussed with regard to the known surface activities and previously demonstrated enzyme inhibitory effects of the drugs


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