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Abstract
Histochemical investigation of 22 corneal discs removed from patients with hereditary macular dystrophy has revealed two types of lesion. One is granulated and lies within and around stromal keratocytes as well as in the endothelium, and is apparently composed of keratan sulfate and a hexose- or deoxyhexose-rich acidic mucosubstance. The other is intralamellar and probably consists of a similar periodate-reactive acidic polysaccharide but without appreciable keratan sulfate.