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RONALD E. SMITH, ALLAN D. JENSEN, ARTHUR M. SILVERSTEIN; Antibody Formation by Single Cells during Experimental Immunogenic Uveitis. Invest. Ophthalmol. Vis. Sci. 1969;8(4):373-380.
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© ARVO (1962-2015); The Authors (2016-present)
The Jerne plaquing technique for the demonstration of single antibody-forming cells was employed to study the kinetics of the antibody response that accompanies experimental immunogenic uveitis in rabbits produced by intravitreal injection of sheep erythrocyte stromas. Prior to the onset of uveitis, a modest increase in antibody formation in the spleen can be detected. With the appearance of uveitis, the proportion in the uveal tract of inflammatory cells that form antibody rapidlyincreases, reaches a peak at about the tenth day, and then slowly declines; 150 days after clinical uveitis has subsided, no antibody-forming cells can be found in the uveal tract. The role of ocular antibody formation in the pathogenesis of recurrent uveitis is discussed.
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