Purchase this article with an account.
Susan Lightman, Rubens Belfort, Rupali K. Naik, Careen Lowder, C. Stephen Foster, Anne M. Rentz, Harry Cui, Scott M. Whitcup, Jonathan W. Kowalski, Dennis A. Revicki; Vision-Related Functioning Outcomes of Dexamethasone Intravitreal Implant in Noninfectious Intermediate or Posterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2013;54(7):4864-4870. https://doi.org/10.1167/iovs.12-10981.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of a single treatment with dexamethasone intravitreal implant (DEX implant) on patient-reported visual functioning in patients with noninfectious intermediate or posterior uveitis.
Patient eyes with noninfectious intermediate or posterior uveitis were randomized to a single treatment with DEX implant 0.70 mg (n = 77), DEX implant 0.35 mg (n = 76), or a sham procedure (n = 76) and followed for 26 weeks. Vision-related functioning was measured using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) assessed at baseline and at weeks 8, 16, and 26 or early exit. Analysis of covariance and mixed model analysis of covariance were used to compare vision-related functioning between the DEX implant 0.70 and 0.35 mg groups and the sham group.
By 8 weeks, the DEX implant 0.70 mg group demonstrated significant improvements in NEI VFQ-25 subscales near vision (P = 0.031), distance vision (P = 0.023), peripheral vision (P = 0.045), vision-specific social functioning (P = 0.019), and the NEI VFQ-25 composite score (P = 0.007) compared with sham. After 26 weeks, the DEX implant 0.70 mg group reported significant improvements in NEI VFQ-25 subscales distance vision (P = 0.003), vision-specific role difficulties (P = 0.038), vision-specific dependency (P = 0.017), vision-specific social functioning (P = 0.009), vision-specific mental health (P = 0.036), and the composite score (P = 0.001) compared with sham.
In patients with noninfectious intermediate or posterior uveitis receiving a single treatment of DEX implant 0.70 mg, significant and clinically meaningful improvements in patient-reported visual functioning were observed as early as week 8 and were maintained over 26 weeks. (ClinicalTrials.gov number, NCT00333814.)
This PDF is available to Subscribers Only