Purchase this article with an account.
THOMAS M. HARRIS, L. BENJAMIN SHEPPARD, WILLIAM M. SHANKLIN, RICHARD R. FOX; A Comparison of Corneal Epithelium Regeneration in Normal and Buphthalmic Rabbits. Invest. Ophthalmol. Vis. Sci. 1970;9(2):122-130.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
A large globe and corneal clouding form an early finding in infantile buphthalmia in both rabbits and human subjects which is frequently associated with fragility and sloughing of the corneal epithelium. The severity of the lesions increases with the severity of the buphthalmia. This study was designed to determine comparatively if the severity of buphthalmia is reflected in the ability of corneal epithelium to regenerate. The epithelium was scraped from 34 rabbit corneas representing five categories of eyes: two normal groups and three buphthalmic. The daily rate of epithelial regeneration was calculated by planimetric measurements taken from enlarged photographs of fluorescein-stained eyes. The actual area of corneal epithelium regenerated daily by each eye is presented in tabular form. When these data were subjected to statistical analysis it was found that in rabbit eyes there is no relation between the severity of buphthalmia and the ability of the eye to regenerate corneal epithelium. Extremely buphthalmic eyes can regenerate as efficiently as the eyes of genetically normal animals from the same colony. There does appear to be a direct relation between the severity of the buphthalmia and the looseness of the regenerated epithelium. It is proposed that this looseness of the buphthalmic corneal epithelium may be related to a deficiency in the basement membrane.
This PDF is available to Subscribers Only