February 1970
Volume 9, Issue 2
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Articles  |   February 1970
Corneal Calcification in Spontaneously Diabetic Mice
Author Affiliations
  • RAINER MITTL
    Department of Ophthalmology of the New York Medical College New York, N. Y.
  • Miles A. Galin
    Department of Ophthalmology of the New York Medical College New York, N. Y.
  • WERNER OPPERMAN
    Department of Medicine of the New York Medical College, New York, N. Y.
  • Rafael A. Camerini-Davalos
    Department of Medicine of the New York Medical College, New York, N. Y.
  • DAVID SPIRO
    Department of Pathology of the New York Medical Collegek, New York, N. Y.
Investigative Ophthalmology & Visual Science February 1970, Vol.9, 137-145. doi:
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      RAINER MITTL, Miles A. Galin, WERNER OPPERMAN, Rafael A. Camerini-Davalos, DAVID SPIRO; Corneal Calcification in Spontaneously Diabetic Mice. Invest. Ophthalmol. Vis. Sci. 1970;9(2):137-145.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A genetically diabetic mouse strain with a high incidence of calcification of the cornea was studied. Biomicroscopic and histopathologic examination of the cornea revealed the presence of calcium in subepithelial and anterior stromal layers. Serum alkaline phosphatase levels were elevated as compared to a control group. Treatment of the corneal lesions with EDTA was only partly successful. The question of a corneal dystrophy or a common metabolic defect causing diabetic features, as well as corneal calcification, is raised.

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