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RAINER MITTL, Miles A. Galin, WERNER OPPERMAN, Rafael A. Camerini-Davalos, DAVID SPIRO; Corneal Calcification in Spontaneously Diabetic Mice. Invest. Ophthalmol. Vis. Sci. 1970;9(2):137-145.
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A genetically diabetic mouse strain with a high incidence of calcification of the cornea was studied. Biomicroscopic and histopathologic examination of the cornea revealed the presence of calcium in subepithelial and anterior stromal layers. Serum alkaline phosphatase levels were elevated as compared to a control group. Treatment of the corneal lesions with EDTA was only partly successful. The question of a corneal dystrophy or a common metabolic defect causing diabetic features, as well as corneal calcification, is raised.
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