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H. BARRY COLLIN; Lymphatic Drainage of 131I-Albumin from the Vascularized Cornea. Invest. Ophthalmol. Vis. Sci. 1970;9(2):146-155.
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The presence of lymphatic vessels in the vascularized rabbit cornea has been demonstrated previously1, 2. In this paper it is shown that an 131I-albumin-Evans blue complex injected into the center of a lymph-vascularized rat cornea may be carried to the lymph nodes of the neck within six minutes. This time corresponds to the time required for the same inoculum to be carried from the bulbar conjunctiva, a lymphalic-rich tissue, to the same lymph nodes. Moreover it is shown that although 131I-albumin can pass through the normal or edematous corneas by a process of diffusion this passage is slow in that the time taken from cornea to lymph nodes is about six hours and the radioactivity in the nodes may be only one thousandth of that found with vascularized corneas. These findings are considered as evidence on a functional level that lymphatic vessels, when present in a vascularized mammalian cornea, are channels of rapid movement of other similar-sized molecules in the cornea, including antigens from a grafted cornea.
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