Table 2A shows the results of multivariable modeling predicting metastasis-free survival for each chromosome aberration, including complete or partial loss of chromosome 3, 1p, 6q, and 8p, and gain of 6p, 6q, 8p, and 8q after adjusting for the effects of the other chromosomal changes. Loss of chromosome 3 (HR = 3.19, 95% CI = 1.27–8.02,
P = 0.014), 1p (HR = 2.16, 95% CI = 1.14–4.06,
P = 0.018), and 8p (HR = 1.97, 95% CI = 1.03–3.77,
P = 0.04) were all significant prognostic factors for poor metastatic outcome. Chromosome 8q-gain was marginally significant in this model (HR = 2.30, 95% CI = 0.99–5.30,
P = 0.052), but had the second highest HR after chromosome 3-loss.
Table 2B shows the results of the multivariate modeling of chromosomal abnormalities after further adjustment for demographic and tumor characteristics. In these models, sex (HR = 2.68, 95% CI = 1.40–5.09,
P = 0.003), tissue source (HR = 2.70, 95% CI = 1.32–5.52,
P = 0.006), and basal diameter (HR = 1.13, 95% CI = 1.04–1.23,
P = 0.006) remained significant after adjusting for the effects of other tumor characteristics and chromosomal losses or gains. Comparison of the results of the effect of chromosome gains or losses without (
Table 2A) and with (
Table 2B) adjustment for demographic and tumor characteristics showed that chromosome 3-loss (HR = 3.19,
P = 0.014 in
Table 2A; and HR = 4.16,
P = 0.007 in 2B) and 8p-loss (HR = 1.97,
P = 0.040 in 2A; and HR = 2.66,
P = 0.010 in 2B) had increased HR values, becoming more significant after adjusting for the effects of the other covariates. In contrast, both chromosome 1p-loss and 8q-gain had lower HR values and were no longer significant after adjusting for the other variables.