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Laurence Shen Lim, Licia Tan, Shamira Perera; Retinal Vessel Oxygen Saturation Increases After Vitrectomy. Invest. Ophthalmol. Vis. Sci. 2014;55(6):3851-3856. doi: https://doi.org/10.1167/iovs.14-14152.
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To evaluate the effects of vitrectomy on retinal vascular oxygen saturation in an adult population.
This was a prospective observational study. Twenty-seven eyes of 27 patients who underwent vitrectomy for macular conditions were included. Retinal oximetry was performed using the Oxymap system prior to vitrectomy and 3 months after surgery and the mean retinal arterial and venous oxygen saturation were measured. The arterial–venous difference (AVD) was calculated as the difference between the arterial and venous saturations. Multivariate linear regression models were constructed to compare oxygen saturation before and after surgery, with adjustments for age, sex, hypertension, hyperlipidemia, diabetes mellitus, and indication for surgery.
The mean age of the subjects was 68.4 ± 8.9 years, 15 (55%) were male and the majority were of Chinese ethnicity (93%). The mean arterial saturation increased significantly after vitrectomy (101.93 ± 8.36% vs. 96.16 ± 14.14%, P = 0.01). The mean venous saturation also increased significantly after surgery (59.76 ± 8.52% vs. 50.40 ± 11.72%, P = 0.02). The mean AVD significantly decreased from 45.76 ± 12.18% before surgery to 42.17 ± 10.94% after surgery (P = 0.02).
Retinal arterial and venous oxygen saturation are significantly increased after vitrectomy, while the AVD is decreased after vitrectomy.
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