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Yukihiro Shiga, Toshifumi Asano, Hiroshi Kunikata, Fumihiko Nitta, Hajime Sato, Toru Nakazawa, Masahiko Shimura; Relative Flow Volume, a Novel Blood Flow Index in the Human Retina Derived From Laser Speckle Flowgraphy. Invest. Ophthalmol. Vis. Sci. 2014;55(6):3899-3904. doi: 10.1167/iovs.14-14116.
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© ARVO (1962-2015); The Authors (2016-present)
We investigated the accuracy and reproducibility of relative flow volume (RFV), a novel index of blood flow in the human retina derived from laser speckle flowgraphy (LSFG).
Pre- and postbranch retinal RFV measurements were compared in 34 retinal venous bifurcations in 34 healthy volunteers (mean age, 49.0 ± 14.8 years) to determine the accuracy of RFV. Next, the coefficient of variation (COV) of RFV was determined for 30 temporal retinal arteries in a second group of 18 healthy volunteers (mean age, 30.3 ± 7.7 years). Finally, laser Doppler velocimetry (LDV) data were obtained from the same study population and compared to RFV data from the retinal vessels.
A comparison of RFV measurements in a trunk vessel of the retina and the sum of its two daughter vessels revealed a strong correlation (r = 0.98, P < 0.001). Reproducibility analysis showed that the COV for RFV was 5.9% ± 3.6%. Linear regression analysis revealed that RFV was correlated significantly with LDV measurements of mean retinal blood velocity (v mean) and retinal blood flow (FLDV, v mean, r = 0.61, P < 0.001; FLDV, r = 0.51, P = 0.004, respectively), but not significantly correlated with ocular perfusion pressure (r = −0.04, P = 0.76).
These results suggest that RFV values obtained with LSFG can be considered an accurate and reliable index of relative blood flow in the human retina. Thus, RFV, a novel LSFG-derived variable, has potential for assessing retinal blood flow alterations in ocular disease.
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