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Pirro G. Hysi, Robert Wojciechowski, Jugnoo S. Rahi, Chris J. Hammond; Genome-Wide Association Studies of Refractive Error and Myopia, Lessons Learned, and Implications for the Future. Invest. Ophthalmol. Vis. Sci. 2014;55(5):3344-3351. doi: 10.1167/iovs.14-14149.
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The investigation of the genetic basis of refractive error and myopia entered a new stage with the introduction of genome-wide association studies (GWAS). Multiple GWAS on many ethnic groups have been published over the years, providing new insight into the genetic architecture and pathophysiology of refractive error. This is a review of the GWAS published to date, the main lessons learned, and future possible directions of genetic studies of myopia and refractive error.
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