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Shinji Ohkubo, Tomomi Higashide, Sachiko Udagawa, Kazuhisa Sugiyama, Masanori Hangai, Nagahisa Yoshimura, Chihiro Mayama, Atsuo Tomidokoro, Makoto Araie, Aiko Iwase, Takashi Fujimura; Focal Relationship Between Structure and Function Within the Central 10 Degrees in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(8):5269-5277. doi: https://doi.org/10.1167/iovs.14-14153.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate which measurements of inner macular thickness are the most useful for evaluating the focal relationship with visual sensitivity within the central 10° in glaucoma and which layers require correction for retinal ganglion cell (RGC) displacement.
Sixty eyes of 60 subjects with glaucoma were included. Sensitivity of each test point of 10-2 standard automated perimetry was compared with the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL+ inner plexiform layer (IPL), and RNFL+GCL+IPL (GCC), with and without RGC displacement, using Spearman's rank correlation coefficients. Visual sensitivity was evaluated by unlogged 1/Lambert (1/L) values.
Retinal nerve fiber layer thickness correlated significantly with the sensitivities of all test points except for some in the papillomacular bundle region when adjusting for RGC displacement (rs = 0.287–0.767, P < 0.05). In the central 5.8°, the GCL and (GCL+IPL) thickness correlated significantly with the sensitivities of all test points when adjusting for RGC displacement (GCL: rs = 0.363–0.729, P < 0.01; (GCL+IPL): rs = 0.359–0.715, P < 0.01). The GCC thickness correlated significantly with the sensitivities of all 68 test points when adjusting for RGC displacement (rs = 0.359–0.767, P < 0.01). RGC displacement improved the correlation between sensitivity and GCL, (GCL+IPL), and GCC in the central 4 points (GCL: rs = from 0.270–0.470 to 0.421–0.540; (GCL+IPL): rs = from 0.195–0.450 to 0.381–0.549; GCC: rs = from 0.132–0.449 to 0.359–0.562).
The GCC is the most useful parameter to evaluate structure and function within the central 10° in glaucoma. Adjusting for RGC displacement is essential to evaluate the relationship between structure of the GCL-related layer and function at the central macula.
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