June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Anti-inflammatory Properties of Resveratrol Improve the Treatment of Diabetic Retinopathy
Author Affiliations & Notes
  • Hamid Ahmadieh
    Ophthalmology, Ophthal Rsch Ctr,Shahid Beheshti Univer. Med. Sci., Tehran, Islamic Republic of Iran
  • Farhad Ghadiri Soufi
    Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar-Abbas, Islamic Republic of Iran
  • Daryoush Mohammad-Nejad
    Histology, Faculty of Medicine,Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran
  • Ali Hafezi-Moghadam
    Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
  • Footnotes
    Commercial Relationships Hamid Ahmadieh, None; Farhad Ghadiri Soufi, None; Daryoush Mohammad-Nejad, None; Ali Hafezi-Moghadam, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 102. doi:
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      Hamid Ahmadieh, Farhad Ghadiri Soufi, Daryoush Mohammad-Nejad, Ali Hafezi-Moghadam; Anti-inflammatory Properties of Resveratrol Improve the Treatment of Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):102.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Resveratrol (trans-3, 5, 4'-trihydroxystilbene) is a nutritional supplement with anti-inflammatory properties. This work investigates the impact of orally administered resveratrol on inflammatory processes in streptozotocin-nicotinamid-induced diabetic retinopathy.

Methods: Male Wistar rats were divided into four groups: normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h fasted rats.

Results: Oral resveratrol administration (5 mg/kg/day for 4 months) significantly improved glucose tolerance and alleviated hyperglycemia and weight loss in diabetic rats. Resveratrol administration significantly improved the elevated levels of nuclear factor kappa B (activity and mRNA), tumor necrosis factor alpha and apoptotic cells in the retinas of the diabetic rats. Resveratrol treated animals showed significantly less disarrangement and reduction in thickness of retinal layers. Compared to control, resveratrol did not affect plasma insulin levels or retinal cyclooxygenase-2 activity.

Conclusions: Long-term resveratrol administration has beneficial anti-inflammatory properties. Resveratrol could prove to be an effective therapeutic supplement in the prevention and treatment of diabetic retinopathy.

Keywords: 499 diabetic retinopathy • 557 inflammation  

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