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Kentaro Nishida, Hirokazu Sakaguchi, Takashi Fujikado, Motohiro Kamei, Kohji Nishida; Optimal electrode conditions for surprachoroidal-transretinal stimulation system to elicit electrically-evoked potentials. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1063. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the effects of the height and the surface area of the stimulating electrode on the electrical evoked potentials (EEPs) elicited by suprachoroidal-transretinal stimulation (STS) in rabbit eye.
A scleral pocket (3x5 mm) was created just over the visual streak in anesthetized rabbits (weight, 2.2-2.5 kg). The STS stimulating electrode system was implanted into the pocket. We varied the height of the stimulating electrode (300µm or 500µm) and the surface of the electrode (smooth or porous, Figure). EEPs were then elicited by each type of electrode conditions. Three sessions were repeated for each group.
For the height of the stimulating electrode, the implicit times of the EEPs were 31.6±0.5 ms (300µm) and 31.9±0.8 ms (500µm), respectively, and the amplitudes were 78.2±9.5 µV (300µm) and 70.0±5.1 µV(500µm) respectively. These differences were not significant (P=0.588; P=0.261). The surface area of the stimulating electrode has no significant effect on the implicit times and the amplitudes of the EEPs (P>0.05).
The height and the surface area of the stimulating electrode do not significantly affect the implicit times and amplitudes of the EEPs elicited by the STS system.
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