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Akiyasu Kanamori, Azusa Akashi, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi; Comparative assessment for the ability of Cirrus, RTVue and 3D OCT to diagnose glaucoma with high myopia. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1444.
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© ARVO (1962-2015); The Authors (2016-present)
This study evaluated the detection ability of circumpapillary retinal nerve fiber layer thickness (cpRNFL) and macular inner retinal layer parameter measurements obtained using Cirrus, RTVue and 3D OCT in glaucoma patients with high myopia.
A total of 71 glaucomatous eyes and 30 normal eyes with high myopia (≦-6.0 diopter) were enrolled in this study. Each participant was imaged using Cirrus, RTVue and 3D OCT to evaluate average and quadrant RNFL thicknesses. Macular retinal nerve fiber layer (mRNFL) thickness, ganglion cell layer + inner plexiform layer (GCL/IPL) and inner retinal layer (IRL) thickness were also analyzed. The areas under the receiver operating characteristic curves (AUCs) of these parameters were compared between the instruments. The sensitivities at fixed specificities (95%) in average cpRNFL and IRL thickness were also evaluated.
These three instruments revealed similar AUCs for cpRNFL thickness in high myopic glaucomatous eyes (Cirrus, 0.974; RTVue, 0.969; 3D OCT, 0.948). The AUCs for the nasal quadrant RNFL thickness measured with RTVue displayed significantly higher AUCs than Cirrus (p<0.001) and 3D OCT (p<0.001). There are no significant differences in the IRL thickness of average and both hemifield sectors between instruments. TheAUCs for the average IRL thickness were 0.938 with Cirrus, 0.954 with RTVue, and 0.959 with 3D OCT. The sensitivities for the detection of high myopic glaucomatous eyes with the average cpRNFL and IRL thickness by Cirrus, RTVue and 3D OCT were 89%, 90%, 85%, and 90%, 92%, 87% at the specificity of 95%, respectively.
The average cpRNFL thicknesses measured by these three OCT instruments exhibited similar abilities in the diagnosis of high myopic glaucoma, but RTVue exhibited better performance than Cirrus and 3D OCT for the nasal quadrant. IRL measured with three instruments also exhibited similar abilities. CpRNFL and IRL measurements offered the good parameters the clinical diagnosis of glaucoma in patients with high myopia.
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