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Sang Woo Park, Jung-Han Choi; Diagnostic Validity of Macular Ganglion Cell-Inner Plexiform Layer Thickness Deviation Map Using Spectral Domain Optical Coherence Tomography in Preperimetric and Early Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1457.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the diagnostic power of ganglion cell-inner plexiform layer thickness deviation map using Cirrus high definition-optical coherence tomography (HD-OCT) to discriminate between the normal controls and patients with preperimetric or early glaucoma
Seventy two normal controls, 37 patients with preperimetric glaucoma and 70 patients with early glaucoma were enrolled in this study. Areas showing abnormal color coding was obtained by customized Image J software calculating the number of abnormal superpixels at 1% and 5% level in the deviation maps of peripapillary retinal nerve fiber layer (pRNFL) measurement and macular ganglion cell-inner plexiform layer (GCIPL) measurement (RNFL-DM1, RNFL-DM5, GCIPL-DM1, GCIPL-DM5). The diagnostic power of deviation map algorithm and each parameters of macular GCIPL and pRNFL measurement in patients with preperimetric or early glaucoma was investigated
Area under the receiver operating curves (AROCs) of the deviation map algorithms in Cirrus HD-OCT ranged between 0.814 and 0.968. Diagnostic parameters with the best AROC were the GCIPL-DM5 (0.920 and 0.968) in both preperimetric and early glaucoma, respectively, and it was more statistically significant in preperimetric glaucoma
GCIPL thickness deviation map showed comparable or superior glaucoma discrimination ability in preperimetric and early glaucoma, compared with other diagnostic parameters. Our findings suggest that, it can be an important parameter in detecting subtle glaucomatous structural change
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