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Elizabeth Verner-Cole, John Campbell, Thomas Hwang, Michael Klein, Steven Bailey; Retinal and choroidal imaging with 870 nm spectral domain OCT compared to 1050 nm spectral domain OCT, with and without enhanced depth imaging. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1479. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to compare images of the retina and choroid obtained with Spectralis (Heidelberg Engineering, Heidelberg, Germany) 1050 nm spectral domain optical coherence tomography (sd-OCT) with and without enhanced depth imaging (EDI) to the commercially available 870 nm sd-OCT with and without EDI. Specifically, the ability to produce high quality images of key anatomical structures in normal eyes and pathologic features in individuals with a variety of macular diseases was evaluated, including age-related macular degeneration, vitreo-retinal interface abnormalities and macular edema due to vein occlusion or diabetes.
Full-length 30° horizontal and vertical scans were obtained, and a reference infrared reflectance image was obtained using the Spectralis eye tracking software, allowing for registration of images from both the 870 nm and 1050 nm instruments. Images with and without EDI were obtained with both wavelengths. Two trained retina physicians blinded to wavelength and EDI status evaluated images assessing the ability to identify the following: clear boundaries of the choriocapillaris, inner segment/outer segment photoreceptor junction, external limiting membrane, retinal pigment epithelium, drusen, retinal edema, vitreo-retinal interface pathology, and subretinal fluid. Separate qualitative analysis of images of the sensory retina (anterior to RPE) and choroid was categorized as superior, equivocal or inferior when compared to the standard 870 nm sd-OCT with EDI. Subfoveal choroidal thickness was measured manually and compared among the four different image types.
Twenty patients underwent Spectralis OCT imaging, of which fourteen patients (twenty two eyes) were ultimately included in the study based on the ability to obtain high quality images. Two eyes demonstrated no macular pathology, and the remainder (some eyes with multiple pathologic findings) showed changes from age-related macular degeneration (10), retinal vascular related macular edema (6) and vitreo-retinal interface abnormalities (13). Images are under review, but results not available at this time.
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