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PREETI GUPTA, Elizabeth Sidhartha, Yih Chung Tham, Jiemin Liao, Ching-Yu Cheng, Tien Wong, Tin Aung, Carol Cheung; Determinants of Macular Thickness using Spectral Domain Optical Coherence Tomography in Healthy Eyes: the Singapore Chinese Eye Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1569.
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To determine ocular and systemic factors influencing macular thickness measured by spectral-domain optical coherence tomography (SD-OCT) in a population-based sample of Chinese adults.
The Singapore Chinese Eye Study is a population-based study in adult Chinese aged 40 to 80 years. All participants underwent a comprehensive eye examination and a standardized interview. A SD-OCT (Cirrus HD-OCT, software version 6.0, Carl Zeiss Meditec, Dublin, CA) with 200 x 200 macular cube scan protocol was used to measure the macular thickness (foveal, average inner, average outer and total average thicknesses). Healthy eyes were defined as eyes with logMAR visual acuity ≤ 0.5, no evidence of macular or vitreoretinal diseases, previous retinal or refractive surgery, past history of intraocular surgery, neurological diseases or glaucoma. Linear regression analyses were performed to study the effects of various ocular and systemic factors on macular thickness.
A total of 490 healthy eyes from 490 Chinese subjects were analysed. The mean (standard deviation) age of the subjects was 53.17 (6.14) years and 50.0% of them were men. The mean central (1 mm diameter), inner (3 mm diameter) and outer (6 mm diameter) macular thicknesses were 250.38 (20.58) µm, 319.33 (14.40) µm and 276.67 (11.94) µm, respectively. The total average macular thickness was 280.25 (11.42) µm and the macular cube volume was 10.09 (0.41) mm3. The central, average inner, total average macular thicknesses and macular cube volume were significantly greater in men than in women (p < 0.005). In multiple linear regression analysis, age was inversely correlated with macular thickness (β = -0.35, p<0.001), after adjusting for gender, diastolic blood pressure, axial length and nuclear opalescence. In addition, increased axial length (AL) was associated with thicker foveal thickness (3.31 mm increase per mm increase in AL, p <0.001) but thinner total average macular thickness (2.27 mm decrease per mm increase in AL, p <0.001).
Older age, female gender and longer AL were independently associated with thinner average inner, average outer and total average macular thicknesses (except AL for average inner macular thickness). These factors should be taken into consideration when interpreting macular thickness measurements with SD-OCT.
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