June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Association of Ambient Solar Radiation with Biomechanical Properties of the Cornea In an elderly population: The Alienor Study
Author Affiliations & Notes
  • Cedric Schweitzer
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
  • Cecile Delcourt
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Florence Malet
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
  • Melanie Le Goff
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Jean-Francois Korobelnik
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Marie Rougier
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
  • Marie-Noelle Delyfer
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Jean Francois Dartigues
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Pascale Barberger-gateau
    INSERM, ISPED, Bordeaux university, bordeaux, France
  • Joseph Colin
    Ophthalmology, University Hospital Pellegrin, Bordeaux, France
  • Footnotes
    Commercial Relationships Cedric Schweitzer, None; Cecile Delcourt, Laboratoires Théa (F), Novartis (C), Bausch+Lomb (C); Florence Malet, None; Melanie Le Goff, None; Jean-Francois Korobelnik, Alcon (C), Allergan (C), Bayer (C), Carl Zeiss Meditec (C), Novartis (C), Thea (F); Marie Rougier, THEA (C), Bausch&Lomb (C), Allergan (C), Kemin (C); Marie-Noelle Delyfer, Thea Laboratories (F); Jean Francois Dartigues, Novartis (F), IPSEN (F); Pascale Barberger-gateau, Danone (F), Vifor Pharma (C); Joseph Colin, Alcon (C), Abbott (C), AdditionTechnology (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1614. doi:
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      Cedric Schweitzer, Cecile Delcourt, Florence Malet, Melanie Le Goff, Jean-Francois Korobelnik, Marie Rougier, Marie-Noelle Delyfer, Jean Francois Dartigues, Pascale Barberger-gateau, Joseph Colin; Association of Ambient Solar Radiation with Biomechanical Properties of the Cornea In an elderly population: The Alienor Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1614.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To analyze the association of ambient solar radiation (SR) on biomechanical properties of the cornea in adult patients.

Methods: The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes) Study is a population-based epidemiological study on age-related eye diseases. In 2009-2010, 625 subjects, aged 75 years or more, had an eye examination, including intraocular pressure, central corneal thickness (CCT) measurements, and an evaluation of the biomechanical properties of the cornea using the ocular response analyser® (ORA®, reichert inc., USA). Mean lifetime ambient SR was estimated using residential history. Global ambient annual SR (a measure of solar energy including all wavelengths) was estimated using astronomic formulas and the statistics of sunshine hours at each location. Then, for each participant, average annual ambient SR was estimated by weighting annual ambient solar radiation at each location by the time spent at that location. Participants were classified in 3 groups (Group 1: <458.53 kJ/cm2, Group 2: 458.53-474.74 kJ/cm2 (reference), Group 3: >474.74 kJ/cm2). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated intraocular pressure (IOPcc), Goldmann correlated intraocular pressure (IOPg) and CCT parameters were analyzed between SR groups, using mixed linear regression models taking into account data from both eyes and their intra-individual correlations.

Results: After adjustment for age and gender, there was a significant association of CH and CRF values with SR higher than 474.74 kJ/cm2 (CH: -0.39mmHg, 95% confidence interval (CI): -0.75;-0.03, p=0.03/ CRF: -0.38mmHg, 95% CI: -0.74; -0.03, p=0.035), whereas there was no significant association of CH and CRF values with SR lower than 458.53 kJ/cm2 (CH: 0.01mmHg, 95% CI: -0.34; 0.36, p=0.96/ CRF: 0.002mmHg, 95% CI: -0.35; 0.35, p=0.99). The CCT was not significantly associated with SR ( SR<458.53: CCT:-2.48µm, 95%CI: -11.93;6.97, p=0.61/ SR> 474.74: CCT: -4.25µm, 95%CI: -13.86;5.35, p=0.38).

Conclusions: CH and CRF were significantly lower in subjects exposed to high ambient solar radiation. Ambient UV exposure might induce histological changes of the cornea that influence its biomechanical properties.

Keywords: 479 cornea: clinical science  
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