Change in Intraocular Pressure and Angle of Eyes with Primary Angle Closure Suspects One Year after Laser Peripheral Iridotomy

Abstract

 

Purpose

 

To report the change in intraocular pressure (IOP), and anterior chamber angle following laser peripheral iridotomy (LPI) in primary angle closure suspects

 

Methods

 

134 bilateral PACS (non-visibility of the posterior trabecular meshwork for ≥ 180 degrees on gonioscopy) ,aged 40 years or more diagnosed as bilateral PACS at HandanEye Hospital, China were randomly assigned to undergo LPI in one eye. Gonioscopy and Goldmann applanation tonometry were performed prior to, on day 7 and 12 months post LPI.

 

Results

 

80 of 134 patients (59.7%) could be followed up at one year. The mean IOP in the treated eyes was 15.9±2.7 mmHg at baseline, 15.4±3.0 mmHg on day 7; 16.5±2.9 mmHg at one month and 15.5±2.9 mmHg at 12 months; the IOP was very similar to the untreated eyes ( p>0.834). One or more quadrants of the angle opened in 93.7% of the LPI treated eyes but 67.0% (53/79) remained closed in two or more quadrants.

 

Conclusions

 

Following LPI the IOP was similar in treated and untreated eyes. Two thirds of the treated eyes continued to have non-visibility of the trabecular meshwork over 180 degrees. Further research is needed to determine the full implications of residual closure as well as the need for follow up and treatment in PACS.

 

 

Intraocular Pressure (IOP) Changes of Before and After Laser Periphearl Iridomoty in The Treated eye and Fellow Untreated Eye

 

 

Flow Chart of Participants in the Trial

 

Keywords: 571 iris • 419 anatomy • 461 clinical (human) or epidemiologic studies: natural history