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Zisis Gatzioufas, Farhad Hafezi, Berthold Seitz; Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1876. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify corneal subbasal nerve density and total number of nerve fibers in primary congenital glaucoma (PCG) and evaluate their impact on corneal sensitivity.
Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry. Mean subbasal nerve density and total number of nerve fibers were quantified by laser-scanning confocal microscopy (LSCM). Normality of data was assessed by Kolmogorov-Smirnov testing. Differences in parameters were assessed with Student’s t test while correlations with CSS with Pearson’s correlation.
Significant differences were identified in the mean subbasal nerve density (2108±692μm in PCG, 2642±484μm in controls, p= 0.003) and total number of nerve fibers (12.3±4.2 in PCG, 15.4±3.1 in controls, p= 0.02). Both groups presented comparable mean CCS and tortuosity. Both groups presented strong correlations between CCS and mean nerve density (r= 0.57 in PCG, r= 0.67 in controls, all p<0.05), and between CCS and total number of nerve fibers (r= 0.55 in PCG, r= 0.56 in controls, all p<0.05).
PCG exerts significant changes both in the mean subbasal nerve density and the total number of nerve fibers. However, these changes do not appear to affect central corneal sensitivity.
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