Structure-Function Relationship between Spectral Domain Optical Coherence Tomography ,Heidelberg Retina Tomograph and Flicker Defined Form Perimetry in Patients with Ocular Hypertension and Preperimetric Glaucoma

Abstract

 

Purpose

 

To assess the correlation between Heidelberg edge perimetry (HEP) and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) Spectralis and by Heidelberg Retina Tomograph III (HRT-III), (Heidelberg Engineering, Heidelberg, Germany).

 

Methods

 

The study involved 60 eyes with ocular hypertension (OHT) and/or optic nerve suspicious for glaucoma without visual field damages detectable with the Standard Automated Perimetry (SAP). All eyes underwent RNFL imaging with Spectralis SD-OCT, topographic imaging HRT-III and Flicker Defined Form Perimetry with HEP. Cohen’s Kappa statistic (k) was used to assess the agreement between SD-OCT and HEP and between HRT and HEP for each of the six RNFL sectors.

 

Results

 

Between Spectralis SD-OCT and HEP agreement was fair (0.38) in the nasal sector, good (0.64-0.68) in the superior temporal and inferior temporal sectors and moderate (0.44-0.52) in the superior nasal, inferior nasal and temporal sectors. Between HRT and HEP agreement was slight (0.14-0.16) in the temporal and inferior temporal sectors, fair (0.24-0.34) in the other sectors.

 

Conclusions

 

The agreement between HEP and Spectralis SD-OCT was better than HEP and HRT. With Spectralis SD-OCT the strongest correlations were found in the superior and inferior temporal sectors as the ISN’T rule suggests for detecting preperimetric RNFL defects.

 

Keywords: 629 optic nerve • 642 perimetry • 610 nerve fiber layer