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Ermengarda Marziani, Laura de Polo, Erma Collaku, Elena Weiszberger, Alessandra Acquistapace, Andrea Giani, Mirella Blini, Giovanni Staurenghi; Structure-Function Relationship between Spectral Domain Optical Coherence Tomography ,Heidelberg Retina Tomograph and Flicker Defined Form Perimetry in Patients with Ocular Hypertension and Preperimetric Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1880.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the correlation between Heidelberg edge perimetry (HEP) and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) Spectralis and by Heidelberg Retina Tomograph III (HRT-III), (Heidelberg Engineering, Heidelberg, Germany).
The study involved 60 eyes with ocular hypertension (OHT) and/or optic nerve suspicious for glaucoma without visual field damages detectable with the Standard Automated Perimetry (SAP). All eyes underwent RNFL imaging with Spectralis SD-OCT, topographic imaging HRT-III and Flicker Defined Form Perimetry with HEP. Cohen’s Kappa statistic (k) was used to assess the agreement between SD-OCT and HEP and between HRT and HEP for each of the six RNFL sectors.
Between Spectralis SD-OCT and HEP agreement was fair (0.38) in the nasal sector, good (0.64-0.68) in the superior temporal and inferior temporal sectors and moderate (0.44-0.52) in the superior nasal, inferior nasal and temporal sectors. Between HRT and HEP agreement was slight (0.14-0.16) in the temporal and inferior temporal sectors, fair (0.24-0.34) in the other sectors.
The agreement between HEP and Spectralis SD-OCT was better than HEP and HRT. With Spectralis SD-OCT the strongest correlations were found in the superior and inferior temporal sectors as the ISN’T rule suggests for detecting preperimetric RNFL defects.
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