June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Platelet Function Influences on Disc Hemorrhages in Patients with Open-Angle Glaucoma
Author Affiliations & Notes
  • Seonghee Shim
    Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
  • Joon Mo Kim
    Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
  • Chul Young Choi
    Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
  • Ki Ho Park
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2250. doi:
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    • Get Citation

      Seonghee Shim, Joon Mo Kim, Chul Young Choi, Ki Ho Park; Platelet Function Influences on Disc Hemorrhages in Patients with Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2250.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate influences of platelet function on disc hemorrhages in patients with open-angle glaucoma.

 
Methods
 

This study included 96 open-angle glaucoma patients with (n=44) and without (n=52) disc hemorrhage. A detailed eye examination including stereo disc photo, red free photo, Humphrey visual field, measurement of RNFL thickness with stratus OCT RNFL thickness, and measurement of collagen/epinephrine (CEPI) closure time with the platelet function analyzer (PFA)-100 system for platelet function assessment were performed in all subjects.

 
Results
 

The two groups were closely matched in terms of the mean ages and gender (p=0.505, p=0.732). There was no significant difference on the prevalence of hypertension and diabetes mellitus (p=0.133, p=0.164, respectively). The CEPI closure time was higher in patients with disc hemorrhage than in those without disc hemorrhage (134.48 ± 50.03 vs 105.98 ± 20.31, p=0.001). The same correlation was observed when platelet function of the two groups were compared by age (Table 1).

 
Conclusions
 

Our results indicate that platelet function influences on disc hemorrhages in patients with open-angle glaucoma. The prolonged bleeding due to delayed platelet aggregation time plays the important role in disc hemorrhages observed in open-angle glaucoma patients.

  
Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment • 627 optic disc  
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