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Seonghee Shim, Joon Mo Kim, Chul Young Choi, Ki Ho Park; Platelet Function Influences on Disc Hemorrhages in Patients with Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2250.
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To evaluate influences of platelet function on disc hemorrhages in patients with open-angle glaucoma.
This study included 96 open-angle glaucoma patients with (n=44) and without (n=52) disc hemorrhage. A detailed eye examination including stereo disc photo, red free photo, Humphrey visual field, measurement of RNFL thickness with stratus OCT RNFL thickness, and measurement of collagen/epinephrine (CEPI) closure time with the platelet function analyzer (PFA)-100 system for platelet function assessment were performed in all subjects.
The two groups were closely matched in terms of the mean ages and gender (p=0.505, p=0.732). There was no significant difference on the prevalence of hypertension and diabetes mellitus (p=0.133, p=0.164, respectively). The CEPI closure time was higher in patients with disc hemorrhage than in those without disc hemorrhage (134.48 ± 50.03 vs 105.98 ± 20.31, p=0.001). The same correlation was observed when platelet function of the two groups were compared by age (Table 1).
Our results indicate that platelet function influences on disc hemorrhages in patients with open-angle glaucoma. The prolonged bleeding due to delayed platelet aggregation time plays the important role in disc hemorrhages observed in open-angle glaucoma patients.
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