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Andre Luiz Silva, Luiz Alberto Melo, Moacyr Campos, Ivan Tavares; Correlation between peripapillary retinal nerve fiber layer thickness and visual field defect in glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2283. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the correlation between peripapillary retinal nerve fiber layer (RNFL) thickness and visual field indices using different spectral-domain optical coherence tomographies (SD-OCT) and visual field perimeters in glaucoma.
A cross-sectional study was carried out. Primary open-angle glaucoma patients were examined using Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany), Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA), RTVue SD-OCT (Optovue, Inc., Freemont, CA), standard automated perimetry (24-2 SITA Standard test, Humphrey Field Analyzer 750, Carl Zeiss Meditec, Dublin, CA), and Frequency Doubling Technology Perimetry (24-2 test, FDT Matrix, Carl Zeiss Meditec, Dublin, CA). The correlation between mean peripapillary RNFL thickness and visual fields indices was analyzed using Spearman rank correlation test.
A total of 44 eyes of 25 patients were included in the study. The mean (standard deviation) peripapillary RNFL thickness obtained by Spectralis, Cirrus, and RTVue were 74.7 (15.9) µm, 72.4 (12.5) µm, and 93.7 (17.4) µm, respectively. The mean (standard deviation) standard automated perimetry Mean Deviation (MD) index was -6.61 (7.12) dB. The RNFL thickness obtained by Spectralis and Cirrus showed similar, moderate correlations with visual field indices (Table). The correlation between RNFL thickness obtained by RTVue and visual field indices were weaker than those obtained by Spectralis and Cirrus OCT (Table).
Moderate correlations between peripapillary RNFL thickness and visual field indices were found in glaucoma patients. The correlation between RNFL thickness obtained by RTVue and visual field indices were weaker than those obtained by Spectralis and Cirrus OCT.
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