DETERMINATION OF OPTIC DISC HEMOGLOBIN QUANTITY IN OCULAR HYPERTENSION, COMPARED WITH OPTICAL COHERENCE TOMOGRAPHY

Abstract

Purpose: To determine the diagnostic capacity of a new method for measuring hemoglobine (Hb) levels at the optic nerve head (ONH), Laguna ONhE (Optic Nerve Hemoglobine) compared with optical coherence tomography (OCT Spectralis) in ocular hypertension (OHT).

Methods: OHT eyes (n=40) and healthy eyes (n=44) underwent a transversal study using TOP G1 perimetry, OCT Spectralis and optic disc retinographies acquired with a non-mydriatic fundus camera (Canon non-mydriatic retinal camera CD-DGi, Canon Inc.,Tokyo, Japan). Laguna ONhE program was used to calculate the Hb amount of the ONH. Area under the receiver operating characteristic curves (AUC) and correlation between structural and functional parameters were determined (Spearman Rho).

Results: The greatest AUC corresponded to Laguna ONhE parameters GDF (Glaucoma Discrimination Function) (0.844 CI 95% 0.762- 0.926), Hemoglobin concentration in the vertical optic disc axis (8 & 20 Sector) (0.817 CI 95% 0.726- 0.907) and C/D Estimated Ratio (0.806 CI 95% 0.714- 0.898), versus the ones obtained for OCT Retinal Nerve Fiber Layer Thickness (RNFL) (0.577 CI 95% 0.439- 0.715).

Conclusions: Discrimination between OHT and controls is better made with Laguna ONhE program than OCT Spectralis in ocular hypertension eyes.

Keywords: 549 image processing • 610 nerve fiber layer • 628 optic flow