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Ignacio Rodriguez-Uña, Carmen Mendez-Hernandez, Manuel González-de-la-Rosa, Federico Saenz-Frances, Paula Arribas Pardo, Jose Martinez de la Casa, Julian Garcia-Feijoo, PI09/90933 of the Instituto de Salud Carlos III grants. Red Temática de Investigación Cooperativa ISCIII: RD07/062; Diagnostic power of the new colorimetry photographic device (Laguna ONhE) in glaucomatous and hypertensive eyes: comparative study with Spectralis optical coherence tomography and HRT III confocal tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2298.
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© ARVO (1962-2015); The Authors (2016-present)
Assessing the diagnostic power of the new device, Laguna ONhE, in the measurements of Optic Nerve Head Hemoglobin (ONHH) versus Spectralis optical coherence tomography (OCT) and confocal tomography (HRT III) in hypertensive and glaucomatous eyes.
Hypertensive (n=36), glaucomatous (n=66) and healthy (n=65) eyes were evaluated using Spectralis OCT, HRT III and non-mydriatic retinography of the Optic Nerve Head (ONH). ONHH was measured using Laguna ONhE software. Areas under ROC curve were calculated and correlation between those parameters with greater diagnostic power was investigated with Spearman Rho coefficient.
The area under ROC curve for Glaucoma Discriminant Function (GDF) index calculated with Laguna ONhE was 0.756 (95% CI: 0.674-0.838). With OCT, the area for retinal nerve fiber layer thickness (RNFLT) was 0.741 (95% CI: 0.654-0.828). With HRT, two parameters were studied: Glaucoma Probability Score (GPS) and vertical cup-disc ratio. The values for the area under the curve were 0.742 (95% CI: 0.656-0.828) and 0.738 (95% CI: 0.652-0.824), respectively. GDF showed the best correlation with GPS of the HRT (-0.609, p<0.01), higher in severe glaucomatous eyes (-0.675) than in early (-0.519) or moderate (-0.450) glaucomatous eyes. GDF correlation with the RNFLT determined by OCT was 0,446 (p<0.01), all glaucomatous eyes considered.
ONHH concentration correlates with Spectralis OCT and HRT III parameters, with similar diagnostic power. The new colorimetry photographic device, Laguna ONhE, might be useful in structural diagnosis of glaucoma.
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