June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Effects of Cataract Surgery and Polymorphisms in CFH and ARMS2 on the risk of Age-related Macular Degeneration
Author Affiliations & Notes
  • Chee Wai Wong
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Tien Wong
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
  • Jiemin Liao
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
  • Gemmy Cheung
    Singapore National Eye Centre, Singapore, Singapore
  • Chiea Chuen Khor
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  • Eranga Vithana
    Singapore Eye Research Institute, Singapore, Singapore
  • Paul Mitchell
    Centre for Vision Research, University of Sydney, Sydney, NSW, Australia
  • Jie Wang
    Centre for Vision Research, University of Sydney, Sydney, NSW, Australia
  • Tin Aung
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
  • Footnotes
    Commercial Relationships Chee Wai Wong, None; Tien Wong, Allergan (C), Bayer (C), Novartis (C), Pfizer (C), GSK (F), Roche (F); Jiemin Liao, None; Gemmy Cheung, Bayer (C), Bayer (R), Bayer (F), Novartis (C), Novartis (S), Glaxo Smith Kline (F), Roche (F); Chiea Chuen Khor, None; Eranga Vithana, None; Paul Mitchell, Novartis (R), Bayer (R); Jie Wang, None; Tin Aung, Alcon (R), Alcon (C), Alcon (F), Allergan (R), Allergan (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Ellex (F), Ellex (R), Santen (R); Ching-Yu Cheng, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 230. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Chee Wai Wong, Tien Wong, Jiemin Liao, Gemmy Cheung, Chiea Chuen Khor, Eranga Vithana, Paul Mitchell, Jie Wang, Tin Aung, Ching-Yu Cheng; Effects of Cataract Surgery and Polymorphisms in CFH and ARMS2 on the risk of Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):230. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To determine the independent and joint effects of cataract surgery and genetic polymorphism in the CFH and ARMS2 genes on the risk of early age-related macular degeneration (AMD)

Methods: A total of 9,529 eyes of 4,918 participants from the Singapore Malay Eye Study and the Singapore Indian Eye Study were analyzed. Participants underwent a structured questionnaire and a detailed ocular examination, including slit lamp examinations for lens status and dilated fundus photography. AMD grading was done based on the retinal photos according to the Wisconsin age-related maculopathy grading system. Previous cataract surgery was defined as pseudophakia or aphakia. Genotyping was performed using Illumina Human 610 BeadChip platform. SNP rs10801555 (Y402H) in the CFH gene and rs3750847 in ARMS2 were included for analysis.

Results: We found a weak association between previous cataract surgery and early AMD (odds ratio [OR]=1.36; 95% confidence interval [CI]: 0.99-1.87). In individuals without previous cataract surgery, the risk of early AMD was similar between those with the CFH Y402H wild-type genotype (GG) and the Y402H risk genotypes (genotype GA: OR = 0.95 [95% CI: 0.72-1.24]; AA: OR = 0.90 [95% CI 0.52-1.55]). In contrast, individuals with both previous cataract surgery and the Y402H risk genotype were more likely to have early AMD, with an OR of 1.63 [95% CI: 1.11-2.41] for the GA genotype and an OR of 2.46 (95% CI: 1.26-4.80) for the AA genotype, compared to those with the GG genotype and without cataract surgery. The interaction between previous cataract surgery and CFH Y402H on the risk of early AMD remained significant (P = 0.045) after adjusting for age, gender, genetic ancestry, smoking status, diabetes mellitus, hypertension, hyperlipidemia and chronic kidney disease. There was no significant interaction between cataract surgery and the ARMS2 rs3750847.

Conclusions: A trend towards an association between cataract surgery and early AMD was found. There is significant gene-environment interaction between CFH genetic polymorphism and cataract surgery on the risk of early AMD, suggesting a role of the complement system in the pathogenesis of AMD following cataract surgery.

Keywords: 412 age-related macular degeneration • 445 cataract • 539 genetics  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×