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Ari Kamei, Eiichiro Nagasaka; The Central Response of the Multi-focal electroretinograms (mf-ERG) and the Threshold of the Static Visual Field (VF) in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2351.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the interrelation of mf-ERG, especially of the second order kernel response in the center and the threshold of static visual field in patients with optic nerve lesions.
Fourteen eyes of fourteen normal volunteers and ten eyes of five patients with optic nerve lesions including anterior ischemic optic neuropathy (AION) and optic tract syndrome were tested. The mf-ERG was recorded with the VERIS Science system 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, pseudo-randomly alternated between black (5cd/m2) and white (200cd/m2) on the CRT monitor. The Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. Recording time was approximately 4min. with dilated pupils having the best-corrected visual acuity. Band pass filter was set from 10 to 100 Hz. Each trace of the 2nd order kernel response was analyzed in the central hexagons. The amplitude of the positive wave around 30msec. was applied for evaluation. The static visual field was examined using the Humphrey Field Analyzer. The foveal threshold was applied for the analysis of the correlation between each measurement value of the 2nd order kernel response.
The positive peak of the 2nd order kernel response in affected eyes became larger than that of unaffected eyes and normal eyes. There was no correlation between the amplitude of positive wave around 30msec. and the foveal threshold.
We demonstrated at ARVO in 2006 that the nasal/temporal amplitude ratio of P1-N2 of the 2nd order kernel response was sensitive to optic nerve lesions (P=0.0000545). If the 2nd order kernel response consists of the Retinal Component (RC) and the Optic Nerve Head Component (ONHC), and the ONHC masks the RC in the unaffected eye, the pure RC appears in the eye with optic nerve lesion which has no response of the ONHC.
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