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Lebriz Ersoy, Albert Caramoy, Tina Ristau, Bernd Kirchhof, Sascha Fauser; Evaluation of Aqueous Flare values in Patients with Cystoid Macular Edema after Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2013;54(15):258.
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To evaluate the role of aqueous flare in pseudophakic eyes with cystoid macular edema (CME) and its relationship to best corrected visual acuity (BCVA) and retinal thickness.
30 pseudophakic eyes with clinically significant CME as well as 46 healthy pseudophakic eyes and 97 healthy phakic eyes as controls were enrolled in this study. BCVA, aqueous flare measurements with a laser flare-cell meter (Kowa FM-500, Kowa Co. Ltd, Tokyo, Japan) and spectral domain optical coherence tomography (SDOCT) volume scans were collected. Foveal central thickness (FCT) was assessed using custom software.
Pseudophakic eyes with CME showed significantly higher flare values than healthy pseudophakic eyes (p<0.0001; median, 22.55 vs. 11.00 photon counts per millisecond (pc/ms)) and phakic eyes (p< 0.0001; median, 22.55 vs. 3.52 pc/ms). There was also a significant difference of flare values between pseudophakic and phakic healthy eyes (p<0.0001; median, 11.00 vs. 3.52 pc/ms). Among pseudophakic eyes, higher flare values correlated significantly with lower BCVA (p= 0.041). Higher flare values also correlated with higher FCT (p<0.0001) in the pseudophakic group.
Analysis of aqueous flare values revealed significant differences between eyes with clinically significant CME and healthy controls indicating higher inflammation levels in the anterior chamber of affected eyes.
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