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Lihong Yang, Jost Jonas, Wen Bin Wei; Optical Coherence Tomography Assisted Enhanced Depth Imaging of Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):259.
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To describe characteristics of central serous chorioretinopathy (CSC) imaged by optical coherence tomography assisted enhanced depth imaging (EDI-OCT).
The prospective observational case series study consisted of patients with acute or chronic CSC. All subjects underwent fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and EDI-OCT.
The study included 68 eyes (68 patients) with 35 eyes showing signs of acute CSC. Mean subfoveal choroidal thickness was 478±114 μm was larger than the normative value from the Beijing Eye Study 2011 (254±107μm) on the same ethnic group. In the hyperfluorescent ICGA areas, EDI-OCT revealed a thinning of the inner choroidal layers and enlargement of the underlying hyporeflective lumina in all eyes. The diameter of the hyporeflective lumina (mean:330±103 μm) was significantly (P<0.001) associated with subfoveal choroidal thickness (correlation coefficient r: 0.68). An RPE detachment was detected in 36 (53%) eyes. A double layer sign defined as an undulated RPE layer and intact underlying Bruch’s membrane (seen in 51 (75%) eyes) was significantly (P=0.025) more often in the chronic CSC-group (29/33;87%) than in the acute CSC-group (22/35;63%). Prevalence of an RPE microrip (8/68;12) eyes) did not differ (P=0.14) between the chronic CSC-group (6/33;18%) and the acute CSC-group (2/35;5.7%).
CSC is characterized by thinned inner choroidal layer and enlarged underlying hyporeflective choroidal lumina in all eyes, in addition to a dome-shaped RPE elevation, a double layer sign of the RPE Bruchs membrane complex, and RPE microrips in some eyes. EDI OCT may be helpful in the diagnosis of CSC.
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