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Seung-Young Yu, Nam Suk Cho, Eung Suk Kim, young gyun Kim, Hyung-Woo Kwak; Fundus Autofluorescence Patterns in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2832.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the patterns and frequency of fundus autofluorescence (FAF) abnormalities in patients with central serous chorioretinopathy (CSC) and evaluate correlation with spectral-domain optical coherence tomography (SD-OCT) findings and best-corrected visual acuity (BCVA)
Cross-sectional observational study, in which 127 eyes of 119 consecutive patients with CSC underwent fundus photography, FAF imaging, fluorescein angiography (FA), indocyanine green angiography (ICGA) and SD-OCT.
The mean age of subjects was 46.5 ± 9.2 years, and 101 (84.9%) were male. Alterations in FAF were classified into five patterns: blocked (43.3%), mottled (8.7%), hyper (27.6%), hyper/hypo (11.0%) and descending tract (9.4%). There are blocked (63.1 ± 156.2 days), mottled (197.9 ± 222.4 days), hyper (379.2 ± 559.7 days), hyper/hypo (987.5 ± 1050.0 days), and descending tract AF group (1363.8 ± 1352.4 days), in order by the length of duration of symptom (p<0.001). The mean visual acuity (logMAR) was 0.24 ± 0.29 for the blocked, 0.36 ± 0.31 for the mottled, 0.36 ± 0.33 for the hyper, 0.51 ± 0.38 for the hyper/hypo, and 0.38 ± 0.32 for the descending tract AF group. The mean visual acuity in the blocked AF group was better to a statistically significant extent (p=0.045, respectively). Ninety-five of 119 patients undergone OCT. Intact inner/outer segment junction on SD-OCT are 39 eyes (100%) in the blocked, 9 eyes (90%) in mottled, 23 eyes (82.1%) in hyper, 3 eyes (37.5%) in hyper/hypo and 3 eyes (30.0%) in descending tract AF group (p=0.000). Disrupted external limiting membrane line on SD-OCT was found in only 1 patient in descending tract group while not being found in other groups.
The FAF abnormalities in CSC show multiple distinct patterns and seem to correlate with duration of symptom and BCVA. A refined phenotypic classification may be helpful to discern chronicity.
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