June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Fundus Autofluorescence Patterns in Central Serous Chorioretinopathy
Author Affiliations & Notes
  • Seung-Young Yu
    Ophthalmology, Kyung Hee University Hospital, Seoul, Republic of Korea
  • Nam Suk Cho
    Ophthalmology, Korea Cancer Center Hospital, Seoul, Republic of Korea
  • Eung Suk Kim
    Ophthalmology, Eulji University Hospital, Daejeon, Republic of Korea
  • young gyun Kim
    Ophthalmology, Eulji General Hospital, Seoul, Republic of Korea
  • Hyung-Woo Kwak
    Ophthalmology, Kyung Hee University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Seung-Young Yu, None; Nam Suk Cho, None; Eung Suk Kim, None; young gyun Kim, None; Hyung-Woo Kwak, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2832. doi:
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      Seung-Young Yu, Nam Suk Cho, Eung Suk Kim, young gyun Kim, Hyung-Woo Kwak; Fundus Autofluorescence Patterns in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2832.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To investigate the patterns and frequency of fundus autofluorescence (FAF) abnormalities in patients with central serous chorioretinopathy (CSC) and evaluate correlation with spectral-domain optical coherence tomography (SD-OCT) findings and best-corrected visual acuity (BCVA)

Methods: Cross-sectional observational study, in which 127 eyes of 119 consecutive patients with CSC underwent fundus photography, FAF imaging, fluorescein angiography (FA), indocyanine green angiography (ICGA) and SD-OCT.

Results: The mean age of subjects was 46.5 ± 9.2 years, and 101 (84.9%) were male. Alterations in FAF were classified into five patterns: blocked (43.3%), mottled (8.7%), hyper (27.6%), hyper/hypo (11.0%) and descending tract (9.4%). There are blocked (63.1 ± 156.2 days), mottled (197.9 ± 222.4 days), hyper (379.2 ± 559.7 days), hyper/hypo (987.5 ± 1050.0 days), and descending tract AF group (1363.8 ± 1352.4 days), in order by the length of duration of symptom (p<0.001). The mean visual acuity (logMAR) was 0.24 ± 0.29 for the blocked, 0.36 ± 0.31 for the mottled, 0.36 ± 0.33 for the hyper, 0.51 ± 0.38 for the hyper/hypo, and 0.38 ± 0.32 for the descending tract AF group. The mean visual acuity in the blocked AF group was better to a statistically significant extent (p=0.045, respectively). Ninety-five of 119 patients undergone OCT. Intact inner/outer segment junction on SD-OCT are 39 eyes (100%) in the blocked, 9 eyes (90%) in mottled, 23 eyes (82.1%) in hyper, 3 eyes (37.5%) in hyper/hypo and 3 eyes (30.0%) in descending tract AF group (p=0.000). Disrupted external limiting membrane line on SD-OCT was found in only 1 patient in descending tract group while not being found in other groups.

Conclusions: The FAF abnormalities in CSC show multiple distinct patterns and seem to correlate with duration of symptom and BCVA. A refined phenotypic classification may be helpful to discern chronicity.

Keywords: 451 chorioretinitis • 550 imaging/image analysis: clinical • 452 choroid  

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