June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Assessing Photoreceptor Structure Following Macular Hole Closure
Author Affiliations & Notes
  • Sean Batson
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Sean Hansen
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Peter Karth
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Robert Cooper
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Drew Scoles
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • David Weinberg
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Alfredo Dubra
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Judy Kim
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • Joseph Carroll
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
  • William Wirostko
    Ophthalmology, Medical College of Wisconsin, Milwaukee, WI
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2839. doi:
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    • Get Citation

      Sean Batson, Sean Hansen, Peter Karth, Robert Cooper, Drew Scoles, David Weinberg, Alfredo Dubra, Judy Kim, Joseph Carroll, William Wirostko; Assessing Photoreceptor Structure Following Macular Hole Closure. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2839.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess foveal photoreceptor structure in eyes that have undergone vitrectomy surgery for closure of macular holes (MH) using spectral-domain optical coherence tomography (SD-OCT) and adaptive optics scanning light ophthalmoscopy (AOSLO).

 
Methods
 

In a prospective case series, 7 eyes of 7 patients were imaged with SD-OCT on an average 4.5 months (range, 2-6) after undergoing pars plana vitrectomy, internal limiting membrane peeling, and gas injection for closure of idiopathic MH. A subset of 4 eyes also underwent simultaneous imaging with AO-SLO, with one of these eyes imaged a second time 12 months after surgery.

 
Results
 

Abnormalities of the ellipsoid portion of the inner segment (ISe) band can be seen near the fovea with SD-OCT, including focal disruption, attenuation, and diffuse mottling. Areas of ISe abnormalities correspond to hyporeflective areas observed on AOSLO. Areas of hyporeflective mosaic disruption can be as small as 100 microns, and may decrease in size between 3 months and 12 months after surgery without “shifting” of the cone mosaic (see Figure 1). Hyper-reflective external limiting membrane structures were also seen with SD-OCT and AOSLO overlying focal ISe lesions.

 
Conclusions
 

Abnormalities of the ISe can be seen with SD-OCT following surgical closure of MH. These changes correspond with hyporeflective areas of cone mosaic disruption on AOSLO. Areas of hyporeflective cone mosaic disruption on AOSLO may decrease in size over time. SD-OCT and AOSLO imaging may be a useful modality to detect and monitor recovery of photoreceptor structure in eyes undergoing surgical closure of MH.

  
Keywords: 586 macular holes • 550 imaging/image analysis: clinical • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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