June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The efficacy and safety of prophylactic cryotherapy in preventing retinal detachment in type 1 Stickler syndrome
Author Affiliations & Notes
  • Gregory Fincham
    Vitreoretinal Service, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom
  • Laura Pasea
    Centre for Applied Medical Statistics, University of Cambridge, Cambridge, United Kingdom
  • Christopher Carroll
    School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
  • Annie McNinch
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
  • Arabella Poulson
    Vitreoretinal Service, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom
  • Allan Richards
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Regional Molecular Genetics Laboratory, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom
  • John Scott
    Vitreoretinal Service, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom
  • Martin Snead
    Vitreoretinal Service, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2848. doi:
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      Gregory Fincham, Laura Pasea, Christopher Carroll, Annie McNinch, Arabella Poulson, Allan Richards, John Scott, Martin Snead; The efficacy and safety of prophylactic cryotherapy in preventing retinal detachment in type 1 Stickler syndrome. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2848.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the efficacy and safety of 360° prophylactic cryotherapy (360PC) according to a standardized protocol and rationale in preventing retinal detachment (RD) in type 1 Stickler syndrome patients.

Methods: A retrospective cohort study. Four hundred and eighty seven type 1 Stickler syndrome patients with both eyes available for study were allocated to a prophylaxis group according to a standardized protocol and rationale (bilateral 360PC) and compared to a control group (no 360PC), or a mixed group (unilateral RD with subsequent unilateral 360PC) and compared to a mixed-control group (unilateral or bilateral RDs with no 360PC) by adjusted multivariant Cox regression and age-matching analyses. All eyes from all patients were also analysed individually to compare the risk of RD with and without prophylaxis, in addition to randomly selecting one eye from each patient for repeated comparison. The main outcome measures were time to RD (including failure of 360PC requiring retinopexy with or without surgery) and side effects resulting from prophylactic treatment.

Results: The control group (n=194) had a greater than seven-fold increased risk of RD compared to the prophylaxis group (n=229) (hazard ratio [HR] = 7.4; 95% confidence interval [CI]: 4.5 - 12.1), with the age-matched control group (n=165) having a five-fold increased risk compared to the age-matched prophylaxis group (n=165) (HR = 5.0; 95% CI: 2.8 - 8.8). Similarly, the mixed-control group (n=104) had a greater than ten-fold increased risk of RD compared to the mixed group (n=64) (HR = 10.3; 95% CI: 5.0 - 21.4), with the age-matched mixed-control group (n=39) having a greater than eight-fold increased risk compared to the age-matched mixed group (n=39) (HR = 8.4; 95% CI: 3.3 - 21.6). Analysis of all individually analysed eyes that received no prophylaxis (n=452) indicated a greater than eleven-fold increased risk of RD compared to those that received 360PC (n=522) (HR = 11.7; 95% CI: 7.9 - 17.2), with a greater than fifteen-fold increased risk calculated when one eye from each patient was randomly selected (HR = 15.4; 95% CI 8.1 - 29.3). Reported side effects from prophylactic treatment were minor and short-lived.

Conclusions: All analyses indicate that prophylactic retinopexy delivered according to this standardized protocol is safe and markedly reduces the risk of retinal detachment in type 1 Stickler syndrome.

Keywords: 697 retinal detachment • 539 genetics • 762 vitreoretinal surgery  
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