Abstract
Purpose:
To describe the main clinical ocular manifestations and the immunosuppressive medication used in Granulomatosis with Polyangiitis in a tertiary eye care center (Insitute of Ophthalmology Conde de Valenciana).
Methods:
Medical records of Granulomatosis with Polyangiitis patients were compiled and reviewed from September 2007 until August 2012. A database was made combining all the ocular clinical manifestations listed. Percentage of occurrence for each ocular disease as a first manifestation in Granulomatosis with Polyangeiitis were obtained and categorized. The immunosuppressive treatment was reviewed too.
Results:
Among the 34 patients identified, 53% have uniocular disease and 47 % have binocular disease. Anterior diffuse scleritis was the most frequent ocular manifestation affecting 32% of the population. Necrotizing scleritis was presented in 29% of the patients. PUK was the first manifestation in 15% of our population. Orbital disease appeared in 9%. Nodular scleritis were identified in 6%. Retinal vasculitis was infrequent affecting only 3% also anterior uveitis (3%). The main medication administered were oral cyclophosphamide and oral methotrexate in 41% of the patients each one, intravenous cyclophosphamide and azathioprine were used in 26.5%. Mycophenolate mofetilo was used in 6%. Only one patient was taking Anti TNF drugs.
Conclusions:
The main ocular manifestation of Granulomatosis with Polyangiitis in our hospital was scleritis and the most common treatment used was oral cyclophosphamide and oral mthotrexate.
Keywords: 745 uvea •
557 inflammation •
459 clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology