June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
OCT characteristics of patients with uveitis with epiretinal membranes, cystoid macular edema, or both
Author Affiliations & Notes
  • Ghazala Datoo O'Keefe
    Ophthalmology, USC Doheny Eye Institute, Los Angeles, CA
  • Hossein Nazari Khanamiri
    Ophthalmology, USC Doheny Eye Institute, Los Angeles, CA
    Department of Ophthalmology, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
  • Narsing Rao
    Ophthalmology, USC Doheny Eye Institute, Los Angeles, CA
  • Footnotes
    Commercial Relationships Ghazala Datoo O'Keefe, None; Hossein Nazari Khanamiri, None; Narsing Rao, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2941. doi:
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      Ghazala Datoo O'Keefe, Hossein Nazari Khanamiri, Narsing Rao; OCT characteristics of patients with uveitis with epiretinal membranes, cystoid macular edema, or both. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2941.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To investigate whether quantitative and qualitative characteristics on spectral domain optical coherence tomography (SD-OCT) correlates with visual acuity and complications of uveitis, i.e. cystoid macular edema (CME), epiretinal membrane (ERM) or both.

Methods: We retrospectively selected all patients with uveitis who were followed at our institute from July 2009 to July 2012 and had CME, ERM or both CME and ERM. Patients were grouped to three groups: 1- Eyes that had CME; 2- Eyes that had ERM; and 3- Eyes with both CME and ERM. Retinal changes as defined by SD-OCT and central foveal thickness were compared among the groups by chi square and Kruskal-Wallis tests respectively . Spearman correlation analysis was used to explore whether there is an association between SD-OCT features, visual acuity, and the above mentioned uveitis complications. The level of significance was considered as less than 0.05.

Results: Of 35 eyes included in the analysis, 4 eyes had only CME, 13 eyes had only ERM, and 18 eyes had both CME and ERM. The central foveal thickness was thinnest in patients with ERM (292 microns±46.1) and thickest in patients with both CME and ERM (409.5 microns±197.3) (p=0.0029). Visual acuity followed the same trend with best visual acuity in the ERM group (0.15±0.29 LogMAR) compared to the CME group (0.35±0.22 LogMAR) and the cystoid macular CME and ERM group (0.38±0.49 LogMAR) but was not statistically significant (p=0.1303). Visual acuity and central foveal thickness did not correlate with each other in the different groups except for patients with both CME and ERM where there was an association if one outlier in the group was removed (p=0.0064).

Conclusions: Simultaneous presence of both CME and ERM trends towards worse VA in patients with uveitis. Eyes with both ERM and CME had the thickest central foveal thickness and lowest visual acuities. Presence of ERM in patients with uveitis is associated with a thinner fovea compared to the eyes complicated with both ERM and CME and eyes with only CME.

Keywords: 557 inflammation • 550 imaging/image analysis: clinical  

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