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Choun-Ki Joo, Jun-Sub Choi; The Effect of Sulfasalazine - Hyaluronic Acid Complex on Posterior Capsule Opacification. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2955.
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The aim of this study was to investigate the effect of sulfasalazine-hyaluronic acid on the development of posterior capsule opacification (PCO) in rabbits
Cataract surgery was performed in rabbit eye (3kg, Male, New Zealand White). During the cataract surgery, The sulfasalazine hyaluronic acid complex was used like a viscoelastic solution. After 1 month of surgery, PCO grading was done by slit-lamp ophthalmic microscopy and PCO grading program. The eyes of the rabbit were enucleated and sections were obtained to observe posterior capsule and other ocular tissues under light microscope
The sulfasalazine-hyaluronic acid complex effectively decreased PCO with both slit-lamp examination and POCO man software assessment. In control group, PCO grade was 1.4 and 0.9 in drug treated group were observed after 1 month. In light microscopy, the lens epithelial cell migration and accumulation were observed on posterior capsule in control eyes. However, the lens epithelial cells on posterior capsule were partially, observed in sulfasalazine-hyaluronic acid complex treated group
The sulfasalazine is an anti-inflammatory drug and a inhibitor of Nuclear factor kappa B. NF-κB is related to the migration and proliferation of LECs. And using sulfasalazine containing hyaluronic acid shows to be effective in inhibiting the migration and proliferation of LECs and decreased PCO formation after cataract surgery in a rabbit.
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