Abstract
Purpose:
The aim of this study was to investigate the effect of sulfasalazine-hyaluronic acid on the development of posterior capsule opacification (PCO) in rabbits
Methods:
Cataract surgery was performed in rabbit eye (3kg, Male, New Zealand White). During the cataract surgery, The sulfasalazine hyaluronic acid complex was used like a viscoelastic solution. After 1 month of surgery, PCO grading was done by slit-lamp ophthalmic microscopy and PCO grading program. The eyes of the rabbit were enucleated and sections were obtained to observe posterior capsule and other ocular tissues under light microscope
Results:
The sulfasalazine-hyaluronic acid complex effectively decreased PCO with both slit-lamp examination and POCO man software assessment. In control group, PCO grade was 1.4 and 0.9 in drug treated group were observed after 1 month. In light microscopy, the lens epithelial cell migration and accumulation were observed on posterior capsule in control eyes. However, the lens epithelial cells on posterior capsule were partially, observed in sulfasalazine-hyaluronic acid complex treated group
Conclusions:
The sulfasalazine is an anti-inflammatory drug and a inhibitor of Nuclear factor kappa B. NF-κB is related to the migration and proliferation of LECs. And using sulfasalazine containing hyaluronic acid shows to be effective in inhibiting the migration and proliferation of LECs and decreased PCO formation after cataract surgery in a rabbit.
Keywords: 652 posterior capsular opacification (PCO)