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Christine Pham Lagler, Wuqaas Munir; Anterior Chamber Depth and Penetrating Keratoplasty Graft Survival. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3076.
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To examine the association between pre-operative anterior chamber depth (ACD) and penetrating keratoplasty graft survival in patients with prior or concomitant intraocular lens placement.
This retrospective study examined cases of penetrating keratoplasty with prior or concomitant intraocular lens placement performed by a single surgeon (WMM) between 2006 and 2011. Cases with missing ACD measurements or immediate post-operative graft complications were excluded. Logistic regression analysis was then performed to determine if there was a statistically significant association between pre-operative ACD and graft failure. Graft failure was defined as irreversible visually compromising corneal edema or opacification at the time of last follow-up. ACD measurements were obtained by manual or immersion A-scan ultrasonography.
Thirty-one eyes in 28 patients were identified as meeting initial study criteria. Ten eyes were subsequently excluded, with 21 eyes remaining. Age ranged from 50-81 years, averaging 68.17 years. There were 9 males and 11 females. There were 10 right eyes and 11 left eyes. Duration of follow-up ranged from 3-60 months, averaging 8 months. There were 4 cases of graft failure identified (4/21, 19%), including 1 re-graft. ACD in these cases ranged from 1.47-3.67mm, averaging 2.48mm. ACD in cases without failure ranged from 2.16-5.48mm, averaging 3.21mm. Logistic regression analysis did not show a statistically significant relationship between ACD and graft failure (p = 0.19, CI = 0.029-2.01).
While limited by a small sample size, our study suggests that there is no significant relationship between pre-operative anterior chamber depth and penetrating keratoplasty graft survival.
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