June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Anterior Chamber Depth and Penetrating Keratoplasty Graft Survival
Author Affiliations & Notes
  • Christine Pham Lagler
    Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston, MA
  • Wuqaas Munir
    Ophthalmology, Boston University School of Medicine, Boston Medical Center, Boston, MA
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3076. doi:
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      Christine Pham Lagler, Wuqaas Munir; Anterior Chamber Depth and Penetrating Keratoplasty Graft Survival. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3076.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To examine the association between pre-operative anterior chamber depth (ACD) and penetrating keratoplasty graft survival in patients with prior or concomitant intraocular lens placement.

Methods: This retrospective study examined cases of penetrating keratoplasty with prior or concomitant intraocular lens placement performed by a single surgeon (WMM) between 2006 and 2011. Cases with missing ACD measurements or immediate post-operative graft complications were excluded. Logistic regression analysis was then performed to determine if there was a statistically significant association between pre-operative ACD and graft failure. Graft failure was defined as irreversible visually compromising corneal edema or opacification at the time of last follow-up. ACD measurements were obtained by manual or immersion A-scan ultrasonography.

Results: Thirty-one eyes in 28 patients were identified as meeting initial study criteria. Ten eyes were subsequently excluded, with 21 eyes remaining. Age ranged from 50-81 years, averaging 68.17 years. There were 9 males and 11 females. There were 10 right eyes and 11 left eyes. Duration of follow-up ranged from 3-60 months, averaging 8 months. There were 4 cases of graft failure identified (4/21, 19%), including 1 re-graft. ACD in these cases ranged from 1.47-3.67mm, averaging 2.48mm. ACD in cases without failure ranged from 2.16-5.48mm, averaging 3.21mm. Logistic regression analysis did not show a statistically significant relationship between ACD and graft failure (p = 0.19, CI = 0.029-2.01).

Conclusions: While limited by a small sample size, our study suggests that there is no significant relationship between pre-operative anterior chamber depth and penetrating keratoplasty graft survival.

Keywords: 479 cornea: clinical science • 420 anterior chamber  
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