Abstract
Purpose:
To examine the association between pre-operative anterior chamber depth (ACD) and penetrating keratoplasty graft survival in patients with prior or concomitant intraocular lens placement.
Methods:
This retrospective study examined cases of penetrating keratoplasty with prior or concomitant intraocular lens placement performed by a single surgeon (WMM) between 2006 and 2011. Cases with missing ACD measurements or immediate post-operative graft complications were excluded. Logistic regression analysis was then performed to determine if there was a statistically significant association between pre-operative ACD and graft failure. Graft failure was defined as irreversible visually compromising corneal edema or opacification at the time of last follow-up. ACD measurements were obtained by manual or immersion A-scan ultrasonography.
Results:
Thirty-one eyes in 28 patients were identified as meeting initial study criteria. Ten eyes were subsequently excluded, with 21 eyes remaining. Age ranged from 50-81 years, averaging 68.17 years. There were 9 males and 11 females. There were 10 right eyes and 11 left eyes. Duration of follow-up ranged from 3-60 months, averaging 8 months. There were 4 cases of graft failure identified (4/21, 19%), including 1 re-graft. ACD in these cases ranged from 1.47-3.67mm, averaging 2.48mm. ACD in cases without failure ranged from 2.16-5.48mm, averaging 3.21mm. Logistic regression analysis did not show a statistically significant relationship between ACD and graft failure (p = 0.19, CI = 0.029-2.01).
Conclusions:
While limited by a small sample size, our study suggests that there is no significant relationship between pre-operative anterior chamber depth and penetrating keratoplasty graft survival.
Keywords: 479 cornea: clinical science •
420 anterior chamber