June 2013
Volume 54, Issue 15
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ARVO Annual Meeting Abstract  |   June 2013
DSAEK: Endothelial cell loss is greater for Pseudophakic Bullous Keratopathy than for Fuchs’ Dystrophy
Author Affiliations & Notes
  • Julia Talajic
    Devers Eye Institute, Portland, OR
  • Mark Terry
    Devers Eye Institute, Portland, OR
  • Michael Straiko
    Devers Eye Institute, Portland, OR
  • Asem Alqudah
    Devers Eye Institute, Portland, OR
  • David Davis-Boozer
    Lions VisionGift, Portland, OR
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3091. doi:
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      Julia Talajic, Mark Terry, Michael Straiko, Asem Alqudah, David Davis-Boozer; DSAEK: Endothelial cell loss is greater for Pseudophakic Bullous Keratopathy than for Fuchs’ Dystrophy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3091.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine whether Fuchs’ endothelial dystrophy eyes and postsurgical bullous keratopathy (PBK) eyes have differing rates of endothelial cell loss and longterm graft survival following Descemet’s stripping automated endothelial keratoplasty (DSAEK).

Methods: A review of 854 cases of DSAEK was performed to compare the survival rate and donor endothelial cell loss between eyes with a pre-operative diagnosis of PBK (n=106) versus that of Fuchs’endothelial dystrophy (n=748). Cell loss at 6, 12, and 24 months post-operatively was compared with student t-tests. Long-term survival was compared with Chi Square test.

Results: The mean cell loss for Fuchs’ versus PBK was 25% versus 30% at 6 months (p=.012), 25% versus 30% at 1 year (p=.078), and 26% versus 40% at 2 years (p<0.001). 6 Fuchs’ eyes (0.8%) versus 4 PBK eyes (3.8%) experienced late endothelial failure (LEF).

Conclusions: Postoperative endothelial cell loss is significantly higher for eyes with PBK than those with Fuchs’ dystrophy, and LEF occurs at a higher rate among PBK patients. Possible mechanisms to explain these differences in cell loss will be discussed.

Keywords: 481 cornea: endothelium • 741 transplantation • 449 cell survival  
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