June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Corneal thickness after posterior lamellar keratoplasty
Author Affiliations & Notes
  • Anders Ivarsen
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • Jesper Hjortdal
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • Nicolaj Aagaard
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • J.Christian Hedegaard
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • Henrik Sejersen
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • Christina Møller
    Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
  • Footnotes
    Commercial Relationships Anders Ivarsen, None; Jesper Hjortdal, Carl Zeiss Meditec (R); Nicolaj Aagaard, None; J.Christian Hedegaard, None; Henrik Sejersen, None; Christina Møller, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3101. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Anders Ivarsen, Jesper Hjortdal, Nicolaj Aagaard, J.Christian Hedegaard, Henrik Sejersen, Christina Møller; Corneal thickness after posterior lamellar keratoplasty. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3101.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: Descemet’s stripping automated keratoplasty (DSAEK) has become the most frequently performed treatment for visually significant endothelial dystrophy. The surgery causes a transient increase in recipient corneal hydration; however, it remains unknown whether structural changes in the recipient cornea also occur.

Methods: Seventy-six patients treated for endothelial dystrophy were followed with routine clinical examination for at least one year after DSAEK. At all visits, central corneal thickness (CCT) was determined with a Haag-Streit optical pachymeter. The difference in CCT from 3 days to 1 year after sugery (ΔCCT = CCT3days - CCT1year) was calculated as a crude measure of postoperative corneal edema. At their latest visit, patients were examined with spectral domain OCT (SD-OCT; Heidelberg Spectralis with anterior segment module) to determine the central thickness of the recipient cornea (recipient corneal thickness; RCT). SD-OCT was also used to determine CCT in a group of normal corneas.

Results: From 1 to 6 years after DSAEK, RCT averaged 490 ± 29 μm, which was significantly less than the CCT of 531 ± 18 μm that was observed with SD-OCT in normal corneas (p < 0.001). RCT measured 487 ± 28 μm after one year (n = 43), 491 ± 29 μm after 2 years (n = 24), and 505 ± 26 μm after 3 to 6 years (n = 9), with a slight but significant increase over time (Pearson’s corr; r2 = 0.06; p = 0.03). Correlating RCT with ΔCCT also showed a significant correlation between postoperative corneal edema and RCT, with more edema causing the recipient cornea to become thinner over time (r2 = 0.11; p = 0.006).

Conclusions: In patients treated with DSAEK for endothelial dystrophy we found corneas to be thinner than normal once the postoperative edema had resolved.The correlation between post-operative edema and RCT may suggest that wash-out of stromal ground substances induce the thinning, with the subsequent gradual increase in thickness being caused by resynthesis of extracellular material. However, the long-lasting nature of the observed changes could also suggest underlying structural abnormalities in endothelial dystrophy.

Keywords: 479 cornea: clinical science • 481 cornea: endothelium • 741 transplantation  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.