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Elia Duh, Samar Al-Swailem, Zhenhua Xu, Samuel Yiu, Lijuan Wu; Expression of the pro-inflammatory molecule RAGE in human pterygia. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3106.
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Inflammation is associated with development and growth of pterygia, including promotion of angiogenesis. The important inflammatory mediators in pterygia are continuing to be defined. RAGE, the Receptor for Advanced Glycation Endproducts, is known to be a strong pro-inflammatory molecule expressed in vascular endothelium and other cell types. In this study, we examined RAGE expression and immunolocalization in human pterygium and normal conjunctival tissue.
Pterygium specimens were obtained during surgery at the King Khaled Eye Specialist Hospital (KKESH). In the same patients, conjunctiva were obtained from the autograft during surgery. Tissue specimens were formalin-fixed and paraffin-embedded. Tissue sections were analyzed by immunohistochemistry with anti-RAGE antibody. Expression and localization of RAGE were evaluated in pterygium and corresponding conjunctiva.
In both pterygium tissue and corresponding conjunctiva, there was expression of RAGE in the epithelium. In addition, other cell types exhibited expression, notably vascular endothelial cells as well as fibroblasts and possibly macrophages. There was distention of endothelial cells in pterygium specimens with associated prominent staining of RAGE in pterygium specimens as compared to normal conjunctiva.
Our data indicate the expression of RAGE in both pterygial tissues and conjunctiva. The prominent expression of RAGE in vascular endothelium in pterygia suggest a possible role of this molecule in promoting the inflammatory process in pterygium progression.
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